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Article

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages.

Emerging microbes & infections - 1 Dec 2024

Wang Qian, Mellis Ian A, Ho Jerren, Bowen Anthony, Kowalski-Dobson Theresa, Valdez Riccardo, Katsamba Phinikoula S, Wu Madeline, Lee Caitlin, Shapiro Lawrence, Gordon Aubree, Guo Yicheng, Ho David D, Liu Lihong

Abstract excerpt

The recently dominant SARS-CoV-2 Omicron JN.1 has evolved into multiple sublineages, with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth advantages, such as KP.2 and KP.3. We investigated these mutations in JN.1, examining their individual and combined effects on immune evasion, ACE2 receptor affinity, and in vitro infectivity. F456L increased resistance to neutralization by human...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39259045
DOI: 10.1080/22221751.2024.2402880
PMCID: PMC11407393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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