Article
Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants.
Nature communications - 4 Sept 2024
Yang Haonan, Guo Huimin, Wang Aojie, Cao Liwei, Fan Qing, Jiang Jie, Wang Miao, Lin Lin, Ge Xiangyang, Wang Haiyan, Zhang Runze, Liao Ming, Yan Renhong, Ju Bin, Zhang Zheng
Abstract excerpt
The Omicron subvariants of SARS-CoV-2, especially for BA.2.86 and JN.1, have rapidly spread across multiple countries, posing a significant threat in the ongoing COVID-19 pandemic. Distinguished by 34 additional mutations on the Spike (S) protein compared to its BA.2 predecessor, the implications of BA.2.86 and its evolved descendant, JN.1 with additional L455S mutation in receptor-binding domains (RBDs), are of...
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