Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.

Neuron - 28 Aug 2003

Jin Peng, Zarnescu Daniela C, Zhang Fuping, Pearson Christopher E, Lucchesi John C, Moses Kevin, Warren Stephen T

Abstract excerpt

Fragile X syndrome carriers have FMR1 alleles, called premutations, with an intermediate number of 5' untranslated CGG repeats between patients (>200 repeats) and normal individuals (<60 repeats). A novel neurodegenerative disease has recently been appreciated in some premutation carriers. As no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye
Share to Fragile X Mental Retardation Protein
Share to Fragile X Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP70 Heat-Shock Proteins

Share to Inclusion Bodies

Share to Nerve Degeneration

Share to Trinucleotide Repeat Expansion

Share to Ubiquitin

Source

Identifiers

PMID: 12948442
DOI: 10.1016/s0896-6273(03)00533-6

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12948442-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.PMID 12948442Read ↗

RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome.Semantic proximity Read ↗

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular DiseasesSemantic proximity Read ↗

Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse model.Semantic proximity Read ↗

Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration.Semantic proximity Read ↗

<i>C9orf72</i> repeat expansions cause neurodegeneration in <i>Drosophila</i> through arginine-rich proteinsSemantic proximity Read ↗

Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila.Semantic proximity Read ↗

Elevated Fmr1 mRNA levels and reduced protein expression in a mouse model with an unmethylated Fragile X full mutation.Semantic proximity Read ↗

Fragile X premutation rCGG repeats impair synaptic growth and synaptic transmission at Drosophila larval neuromuscular junction.Semantic proximity Read ↗

Fibroblast phenotype in male carriers of FMR1 premutation alleles.Semantic proximity Read ↗

Mouse models of fragile X-related disorders.Semantic proximity Read ↗

Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles.Semantic proximity Read ↗

Fragile X Premutation rCGG Repeats Impairs Synaptic Growth and Synaptic Transmission at <i>Drosophila</i> larval Neuromuscular JunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.