Article
Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.
Cell reports - 17 Oct 2017
Heuser Christoph, Gotot Janine, Piotrowski Eveline Christina, Philipp Marie-Sophie, Courrèges Christina Johanna Felicia, Otte Martin Sylvester, Guo Linlin, Schmid-Burgk Jonathan Leo, Hornung Veit, Heine Annkristin, Knolle Percy Alexander, Garbi Natalio, Serfling Edgar, Evaristo César, Thaiss Friedrich, Kurts Christian
Abstract excerpt
Regulatory T cells (Tregs) prevent autoimmunity but limit antitumor immunity. The canonical NF-κB signaling pathway both activates immunity and promotes thymic Treg development. Here, we report that mature Tregs continue to require NF-κB signaling through IκB-kinase β (IKKβ) after thymic egress. Mice lacking IKKβ in mature Tregs developed scurfy-like immunopathology due to death of peripheral FoxP3+ Tregs. Also,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.