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Article

Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation.

Mediators of inflammation - 1 Jan 2015

Hermouet Sylvie, Bigot-Corbel Edith, Gardie Betty

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with mutation(s) in the JAK2, MPL, or CALR genes. Yet the roles played by these mutations in the...

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Source

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Identifiers

PMID: 26538820
DOI: 10.1155/2015/145293
PMCID: PMC4619950

Genes

JAK2
CALR
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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