Article

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

2022-01-28

Abstract excerpt

The dysregulation of ETS family transcription factors drives human prostate cancer. The majority of prostate cancer is the result of chromosomal rearrangements that lead to aberrant ETS gene expression. The mechanisms that lead to fusion independent ETS factor upregulation and prostate oncogenesis remain unknown. Here, we show that two neighboring transcription factors, Capicua ( CIC ) and ETS2 repressor factor (...

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Literature Corpus work: e3a7a50d-b73e-56d2-bb93-ec2ff8b303d9
DOI: 10.1101/2022.01.26.477820

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