Article

Inflammatory Modulation of Bronchial Epithelial Cells’ Response to Lipopolysaccharide with Pretreatment by Montelukast

2021-04-05

Abstract excerpt

<title>Abstract</title> <p>Purpose Montelukast, a leukotriene receptor antagonist, is the most prescribed non-steroidal anti-inflammatory drug used as add-on therapy at later stages of asthma to prevent disease progression. Besides its direct anti-inflammatory effect due to blocking leukotriene action, montelukast has been proposed to have secondary anti-inflammatory and anti-fibrotic properties. This study aime...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf703140-ca5c-50f0-ad53-79ea13256ffc
DOI: 10.21203/rs.3.rs-389828/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inflammatory Modulation of Bronchial Epithelial Cells’ Response to Lipopolysaccharide with Pretreatment by MontelukastDOI 10.21203/rs.3.rs-389828/v1Read

MicroRNA‑16 regulates lipopolysaccharide‑induced inflammatory factor expression by targeting TLR4 in normal human bronchial epithelial cellsSemantic proximity Read

Development of Inflammatory Models Using Differentiated Human Bronchial Epithelial (HBE) Cells from Cystic Fibrosis Patients for the Pre-Clinical Evaluation of Novel Therapeutic CompoundsSemantic proximity Read

Title：IRAK-M has effects in regulation of lung epithelial inflammation through JNK and p38 MAPK pathwaysSemantic proximity Read

Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial CellsSemantic proximity Read

Genetic polymorphism of transforming growth factor β1 and tumor necrosis factor α is associated with asthma and modulates the severity of asthma.Semantic proximity Read

Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment.Semantic proximity Read

Controversy surrounding the increased expression of TGFβ1 in asthmaSemantic proximity Read

Evaluation of the Efficacy of Omega-3 Fatty Acids Formulations in the Lipopolysaccharide-Induced Acute Lung Inflammation Rat ModelSemantic proximity Read

MicroRNA-27a-5p downregulates the expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via NF-κB signaling pathwaySemantic proximity Read

TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathways in bronchial epithelial cellsSemantic proximity Read

Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.Semantic proximity Read

MiR-146b protects against pediatric pneumonia progression through MyD88/NF-κB signaling pathwaySemantic proximity Read