Article

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

2021-05-12

Abstract excerpt

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function in human fibrosis (Jones et al., 2018). Here, through human tissue, bioinformatic and ex vivo studies we show that hypoxia-inducible factor (HIF) pathway activation...

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Literature Corpus work: e3453b04-14fb-59fe-8213-478f45ae484d
DOI: 10.1101/2021.05.11.443615

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