Article

Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

2021-04-20

Abstract excerpt

The COVID-19 pandemic has demonstrated the need for exploring different diagnostic and therapeutic modalities to tackle future viral threats. In this vein, we propose the idea of sentinel cells, cellular biosensors capable of detecting viral antigens and responding to them with customizable responses. Using SARS-CoV-2 as a test case, we developed a live cell sensor (SARSNotch) using a de novo-designed protein bind...

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Literature Corpus work: e33beb2c-fcfe-5e8c-9fe6-9a7bf9c74e5a
DOI: 10.1101/2021.04.20.440678

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