Article
Recreating the biological steps of viral infection on a cell-free bioelectronic platform to profile viral variants of concern.
Nature communications - 3 Jul 2024
Chao Zhongmou, Selivanovitch Ekaterina, Kallitsis Konstantinos, Lu Zixuan, Pachaury Ambika, Owens Róisín, Daniel Susan
Abstract excerpt
Viral mutations frequently outpace technologies used to detect harmful variants. Given the continual emergence of SARS-CoV-2 variants, platforms that can identify the presence of a virus and its propensity for infection are needed. Our electronic biomembrane sensing platform recreates distinct SARS-CoV-2 host cell entry pathways and reports the progression of entry as electrical signals. We focus on two necessary...
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