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Article

NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.

Breast cancer research and treatment - 1 Aug 2021

Matossian Margarite D, Elliott Steven, Van Hoang T, Burks Hope E, Wright Maryl K, Alzoubi Madlin S, Yan Thomas, Chang Tiffany, Wathieu Henri, Windsor Gabrielle O, Hartono Alifiani Bo, Lee Sean, Zuercher William J, Drewry David H, Wells Carrow, Kapadia Nirav, Buechlein Aaron, Fang Fang, Nephew Kenneth P, Collins-Burow Bridgette M, Burow Matthew E

Abstract excerpt

PURPOSE: Breast cancer remains a prominent global disease affecting women worldwide despite the emergence of novel therapeutic regimens. Metastasis is responsible for most cancer-related deaths, and acquisition of a mesenchymal and migratory cancer cell phenotypes contributes to this devastating disease. The utilization of kinase targets in drug discovery have revolutionized the field of cancer research but...

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PMID: 34196902
DOI: 10.1007/s10549-021-06295-4

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