Article

Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant

2022-12-15

Abstract excerpt

<h4>ABSTRACT</h4> TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using ImmunoChip data from 3,939 juvenile idiopathic arthritis (JIA) patients and 14,412 controls, we identified 132 plausible common non-coding variants, reduced serially by SNP-seq, electrophoretic mobility shift, and luc...

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Literature Corpus work: e2f0f5a0-9452-563a-a8ba-8f9cf853cc18
DOI: 10.1101/2022.12.15.520628

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