Article
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
Human molecular genetics - 1 Aug 2008
Barton Anne, Thomson Wendy, Ke Xiayi, Eyre Steve, Hinks Anne, Bowes John, Gibbons Laura, Plant Darren, Wilson Anthony G, Marinou Ioanna, Morgan Ann, Emery Paul, Steer Sophia, Hocking Lynne, Reid David M, Wordsworth Paul, Harrison Pille, Worthington Jane
Abstract excerpt
Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case...
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