Article

RNA beacons for detecting the human testis-determining factor

2021-04-22

Abstract excerpt

The testis-determining factor (TDF) is an essential transcriptional protein for male differentiation in mammals, expressed along spermatids to early zygotes and, to some extent, in diverse cellular lines. In this study, we developed fluorescent biosensors capable of indicating the presence of TDF. We used in vitro evolution techniques to produce RNA aptamers that bind the recombinantly expressed HMG-box, the DNA...

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Literature Corpus work: e2cac535-810a-508e-87a3-a94c6683f36d
DOI: 10.1101/2021.04.22.440928

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