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Article

Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study.

PLoS genetics - 1 Oct 2020

Galardini Marco, Clermont Olivier, Baron Alexandra, Busby Bede, Dion Sara, Schubert Sören, Beltrao Pedro, Denamur Erick

Abstract excerpt

The genus Escherichia is composed of several species and cryptic clades, including E. coli, which behaves as a vertebrate gut commensal, but also as an opportunistic pathogen involved in both diarrheic and extra-intestinal diseases. To characterize the genetic determinants of extra-intestinal virulence within the genus, we carried out an unbiased genome-wide association study (GWAS) on 370 commensal, pathogenic...

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PMID: 33112851
DOI: 10.1371/journal.pgen.1009065
PMCID: PMC7592755

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