Article
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes
2021-05-03
Abstract excerpt
Type 1 diabetes is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothelial cells (EC) lining capillary walls into the islets of Langerhans, interaction of T cells with macrophages in the islets, and killing of β-cells by autoreactive CD8 + T...
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Identifiers and source
- Literature Corpus work
- e2b62236-d138-541e-bf89-9c318393e0ea
- DOI
- 10.1101/2021.05.03.441837