Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants.

doi:10.3389/fendo.2021.648284

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Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants.

Frontiers in endocrinology - 1 Jan 2021

Heller Sandra, Melzer Michael Karl, Azoitei Ninel, Julier Cécile, Kleger Alexander

Abstract excerpt

Diabetes, as one of the major diseases in industrial countries, affects over 350 million people worldwide. Type 1 (T1D) and type 2 diabetes (T2D) are the most common forms with both types having invariable genetic influence. It is accepted that a subset of all diabetes patients, generally estimated to account for 1-2% of all diabetic cases, is attributed to mutations in single genes. As only a subset of these...

Topics

Animals
CRISPR-Cas Systems
Cell Differentiation
Cell Lineage
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Embryonic Stem Cells
Epigenesis, Genetic
Gene Editing
Genetic Variation
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insulin

Insulin-Secreting Cells

Mice

Mice, Knockout

Mutation

Pancreas

Source

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Identifiers

PMID: 34079523
DOI: 10.3389/fendo.2021.648284
PMCID: PMC8166226

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