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Generation of pluripotent stem cells from patients with type 1 diabetes

31 Aug 2009

Abstract excerpt

Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription...

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PMID: 19720998
DOI: 10.1073/pnas.0906894106

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