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Article

Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology.

Frontiers in endocrinology - 1 Jan 2021

Joshi Kriti, Cameron Fergus, Tiwari Swasti, Mannering Stuart I, Elefanty Andrew G, Stanley Edouard G

Abstract excerpt

Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro models of monogenic human disorders. This is possible because, by and large, the phenotypic consequences of such genetic variants are often confined to a specific and known cell type, and the genetic variants themselves can be clearly identified and controlled for using a standardized genetic background. In contrast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33868170
DOI: 10.3389/fendo.2021.635662
PMCID: PMC8047192

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