Article

Chromatin Topology Reorganization and Transcription Repression by PML/RARα in Acute Promyeloid Leukemia

2020-03-06

Abstract excerpt

<h4>Background</h4> Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML/RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML/RARα in leukemogenesis remains largely unknown. <h4>Results</h4> Using an inducible system, we comprehensively analyzed the 3D genome organization in myeloid cells and its reorganization after PML/RARα inducti...

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Literature Corpus work: e27c4487-b056-5736-b89b-e7477068cffe
DOI: 10.1101/2020.03.05.979070

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