CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress

Abstract excerpt

<title>Abstract</title> <p>MicroRNAs (miRNAs) play pivotal roles in the tumor microenvironment. Here, we analyzed miRNAs in tumor stromal fibroblasts. Expression of miR-224-3p in cancer-associated fibroblasts (CAF) from scirrhous gastric cancer patients was lower than in normal fibroblasts (NF). Introduction of a miR-224-3p mimic attenuated migration and invasion of CAF. By contrast, a miR-224-3p inhibitor augmen...

Topics

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• Autophagy in Disease and Therapy
• Cancer-related molecular mechanisms research
• Carcinoma, Pancreatic Ductal
• Cholangiocarcinoma and Gallbladder Cancer Studies
• Endoplasmic Reticulum Stress and Disease
• In Situ Hybridization, Fluorescence
• MicroRNA in disease regulation
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

e2515a9d-df77-5751-ab69-5a76af263169

DOI

10.21203/rs.3.rs-1863465/v1