Article
Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma.
Oncogene - 6 Aug 2015
Radulovich N, Leung L, Ibrahimov E, Navab R, Sakashita S, Zhu C-Q, Kaufman E, Lockwood W W, Thu K L, Fedyshyn Y, Moffat J, Lam W L, Tsao M-S
Abstract excerpt
Using integrative genomics and functional screening, we identified coiled-coil domain containing 68 (CCDC68) as a novel putative tumor suppressor gene (TSG) in pancreatic ductal adenocarcinoma (PDAC). CCDC68 allelic losses were documented in 48% of primary PDAC patient tumors, 50% of PDAC cell lines and 30% of primary patient derived xenografts. We also discovered a single nucleotide polymorphism (SNP) variant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.