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Article

Cell geometry dictates TNFα-induced genome response

1 May 2017

Abstract excerpt

Cells in physiology integrate local soluble and mechanical signals to regulate genomic programs. Whereas the individual roles of these signals are well studied, the cellular responses to the combined chemical and physical signals are less explored. Here, we investigated the cross-talk between cellular geometry and TNFα signaling. We stabilized NIH 3T3 fibroblasts into rectangular anisotropic or circular isotropic...

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PMID: 28461498
DOI: 10.1073/pnas.1618007114

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