Article
Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype.
ACS applied materials & interfaces - 30 Dec 2015
Luu Thuy U, Gott Shannon C, Woo Bryan W K, Rao Masaru P, Liu Wendy F
Abstract excerpt
Controlling the interactions between macrophages and biomaterials is critical for modulating the response to implants. While it has long been thought that biomaterial surface chemistry regulates the immune response, recent studies have suggested that material geometry may in fact dominate. Our previous work demonstrated that elongation of macrophages regulates their polarization toward a pro-healing phenotype. In...
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