Article

Genomic and Functional studies identify <i>RPSA</i> as a risk gene for ALS and other neurological diseases

2025-07-28

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by motor neuron deterioration. Genetic factors play a significant role in all cases, with 15 genome-wide significant study (GWAS) risk loci identified to date. Follow-up of these loci is a powerful strategy for research translation, as drug targets supported by genetic evidence are more likely to succeed in clinical develo...

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Literature Corpus work: e22ecb1b-f053-589a-8e43-b506c92dd27c
DOI: 10.1101/2025.07.28.25332301

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