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Article

State of play in amyotrophic lateral sclerosis genetics.

Nature neuroscience - 1 Jan 2014

Renton Alan E, Chiò Adriano, Traynor Bryan J

Abstract excerpt

Considerable progress has been made in unraveling the genetic etiology of amyotrophic lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the third most common neurodegenerative disease overall. Here we review genes implicated in the pathogenesis of motor neuron degeneration and how this new information is changing the way we think about this fatal disorder. Specifically, we...

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Identifiers

PMID: 24369373
DOI: 10.1038/nn.3584
PMCID: PMC4544832

Genes

FUS
OPTN
PFN1
SOD1
TARDBP
UBQLN2
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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