Article

Genetic and phenotype analyses of primary lateral sclerosis datasets from international cohorts

2023-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Primary lateral sclerosis (PLS) is the rarest form of motor neurone disease (MND). It is characterized by upper motor neuron degeneration, leading to progressive weakness, spasticity and functional disability. Although PLS does not typically shorten life substantially, it gradually impacts quality of life as the diseases progresses. There is no established genetic cause of PLS. One of the biggest...

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Literature Corpus work: f3046ee1-78c0-517e-a1dc-c5a33cb15c79
DOI: 10.1101/2023.07.19.23292817

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