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Knockout of liver fluke granulin, <i>Ov-grn-1</i> , impedes malignant transformation during chronic infection with <i>Opisthorchis viverrini</i>

2021-12-11

Abstract excerpt

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor for cholangiocarcinoma (CCA) in the Mekong Basin countries of Thailand, Lao PDR, Vietnam, Myanmar and Cambodia. Using a novel model of CCA, involving infection with gene-edited liver flukes in the hamster during concurrent exposure to dietary nitrosamine, we explored the role of the fluke granulin-like growth factor Ov...

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Identifiers and source

Literature Corpus work
e21440fd-d7fe-52b8-8abe-9f7f658cc0a4
DOI
10.1101/2021.12.10.472085
Open publication

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Knockout of liver fluke granulin, <i>Ov-grn-1</i> , impedes malignant transformation during chronic infection with <i>Opisthorchis viverrini</i>DOI 10.1101/2021.12.10.472085
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