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Article

Carcinogenic Liver Fluke Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype.

The Journal of infectious diseases - 15 Nov 2015

Chaiyadet Sujittra, Sotillo Javier, Smout Michael, Cantacessi Cinzia, Jones Malcolm K, Johnson Michael S, Turnbull Lynne, Whitchurch Cynthia B, Potriquet Jeremy, Laohaviroj Marut, Mulvenna Jason, Brindley Paul J, Bethony Jeffrey M, Laha Thewarach, Sripa Banchob, Loukas Alex

Abstract excerpt

BACKGROUND: Throughout Asia, there is an unprecedented link between cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple processes, including chronic inflammation and secretion of parasite proteins into the biliary epithelium, drive infection toward cancer. Until now, the mechanism and effects of parasite protein entry into cholangiocytes was unknown. METHODS: Various microscopy...

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Identifiers

PMID: 25985904
DOI: 10.1093/infdis/jiv291
PMCID: PMC4621255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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