Article
Liver fluke granulin promotes extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma.
Neoplasia (New York, N.Y.) - 1 May 2020
Arunsan Patpicha, Chaidee Apisit, Cochran Christina J, Mann Victoria H, Tanno Toshihiko, Kumkhaek Chutima, Smout Michael J, Karinshak Shannon E, Rodpai Rutchanee, Sotillo Javier, Loukas Alex, Laha Thewarach, Brindley Paul J, Ittiprasert Wannaporn
Abstract excerpt
Crosstalk between malignant and neighboring cells contributes to tumor growth. In East Asia, infection with the liver fluke is a major risk factor for cholangiocarcinoma (CCA). The liver fluke Opisthorchis viverrini secretes a growth factor termed liver fluke granulin, a homologue of the human progranulin, which contributes significantly to biliary tract fibrosis and morbidity. Here, extracellular vesicle...
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