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Article

Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis

1 Mar 2018

Abstract excerpt

Transcriptional co-activator Prdm16 controls brown fat development and white fat browning, but how this thermogenic function is modulated post-translationally is poorly understood. Here, we report that Cbx4, a Polycomb group protein, is a SUMO E3 ligase for Prdm16 and that Cbx4-mediated sumoylation of Prdm16 is required for thermogenic gene expression. Cbx4 expression is enriched in brown fat and is induced in...

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Identifiers

PMID: 29539416
DOI: 10.1016/j.celrep.2018.02.057

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