Article

Epstein-Barr virus promotes survival through germinal center light zone chromatin architecture

2020-10-22

Abstract excerpt

<h4>ABSTRACT</h4> BFL-1 is an understudied anti-apoptotic protein upregulated in cancer and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs). We have previously shown that BFL-1 is regulated through viral EBNA3A-mediated alterations in B-cell chromatin conformation (Price et al., 2017). Here, we extend those findings to define cis- and trans-acting factors that regulate BFL-1 in LCLs and rel...

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Literature Corpus work: e1e3188e-bfc3-545e-a113-c0880468d97f
DOI: 10.1101/2020.10.22.350108

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