Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.

doi:10.1038/s41586-023-05697-2

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Article

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.

Nature - 1 Mar 2023

Chen Da-Yuan, Chin Chue Vin, Kenney Devin, Tavares Alexander H, Khan Nazimuddin, Conway Hasahn L, Liu GuanQun, Choudhary Manish C, Gertje Hans P, O'Connell Aoife K, Adams Scott, Kotton Darrell N, Herrmann Alexandra, Ensser Armin, Connor John H, Bosmann Markus, Li Jonathan Z, Gack Michaela U, Baker Susan C, Kirchdoerfer Robert N, Kataria Yachana, Crossland Nicholas A, Douam Florian, Saeed Mohsan

Abstract excerpt

The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than other major viral variants that have so far been recognized1-12. The Omicron spike (S) protein, which has an unusually large number of mutations, is considered to be the main driver of these phenotypes. Here we generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron (BA.1 lineage) in the backbone of an ancestral...

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PMID: 36630998
DOI: 10.1038/s41586-023-05697-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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