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Article

A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity.

EBioMedicine - 1 Dec 2024

Li Yuhan, Zhang Xianwen, Tai Wanbo, Zhuang Xinyu, Shi Huicheng, Liao Shumin, Yu Xinyang, Mei Rui, Chen Xingzhao, Huang Yanhong, Liu Yubin, Liu Jianying, Liu Yang, Zhu Yibin, Wang Penghua, Tian Mingyao, Yu Guocan, Li Liang, Cheng Gong

Abstract excerpt

BACKGROUND: Global dissemination of SARS-CoV-2 Omicron sublineages has provided a sufficient opportunity for natural selection, thus enabling beneficial mutations to emerge. Characterisation of these mutations uncovers the underlying machinery responsible for the fast transmission of Omicron variants and guides vaccine development for combating the COVID-19 pandemic. METHODS: Through systematic bioinformatics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39531918
DOI: 10.1016/j.ebiom.2024.105437
PMCID: PMC11603013

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