Article

A Myasthenia Gravis genomewide association study of three cohorts identifies Agrin as a novel risk locus

2020-10-27

Abstract excerpt

<h4>Background</h4> Myasthenia Gravis (MG) is a rare autoimmune disorder affecting the neuromuscular junction. Here, we investigate the genetic architecture of MG performing a genomewide association study (GWAS) of the largest MG dataset analyzed to date. <h4>Methods</h4> We integrated GWAS from three different datasets (1,401 cases, 3,508 controls) and performed MG GWAS and onset-specific analyses. We also carrie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1bc5b3c-1fee-55f5-a02d-0a8ebbeaacd5
DOI: 10.1101/2020.10.26.20219261

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Myasthenia Gravis genomewide association study of three cohorts identifies Agrin as a novel risk locusDOI 10.1101/2020.10.26.20219261Read

Myasthenia gravis genome-wide association study implicates AGRN as a risk locus.Semantic proximity Read

Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Semantic proximity Read

HLA-DQB1*05:02, *05:03, and *03:01 alleles as risk factors for myasthenia gravis in a Spanish cohort.Semantic proximity Read

Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.Semantic proximity Read

Recent advances in genetic predisposition of myasthenia gravis.Semantic proximity Read

Genetic and mechanistic overlap between Alzheimer’s disease and myasthenia gravis: insights into neuro-immune crosstalkSemantic proximity Read

Genetic basis of myasthenia gravis - a comprehensive review.Semantic proximity Read

Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA AssociationsSemantic proximity Read

A genome-wide association study of myasthenia gravis.Semantic proximity Read

Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population.Semantic proximity Read

Whole-genome analysis in Korean patients with autoimmune myasthenia gravis.Semantic proximity Read

Timing and localization of myasthenia gravis-related gene expressionSemantic proximity Read