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A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth

1 Apr 2005

Abstract excerpt

Microtubules are among the most successful targets for anticancer therapies and for the development of new anticancer drugs. A-432411 is a novel small molecule that destabilizes microtubules at high concentration and disrupts normal spindle formation at low concentration. A-432411 is an indolinone that is structurally different from other known synthetic microtubule inhibitors. This compound is efficacious...

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PMID: 15827329
DOI: 10.1158/1535-7163.mct-04-0229

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