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Genetic Polymorphisms in Human CX3CR1-Mediated Macrophage Dysregulation are Associated with the Worsening of Hearing Loss and Cochlear Degeneration After Noise Trauma: A Study in a Humanized Mouse Model

2025-05-13

Abstract excerpt

<title>Abstract</title> <p>Sensorineural hearing loss (SNHL) is characterized by cochlear inflammation, macrophage activation, and degeneration of hair cells, synapses and neuron. Macrophage-mediated inflammation in the damaged cochlea is regulated via CX3CR1-CX3CL1 signaling, where the fractalkine ligand CX3CL1 serves as a chemotactic and calming signal for macrophage activation. Furthermore, disrupted CX3CR1-CX...

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Literature Corpus work: e17af5f4-7711-5eed-ad33-f5f8bc42f450
DOI: 10.21203/rs.3.rs-6578570/v1

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