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Article

Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Feb 2018

Chiocchetti Andreas G, Yousaf Afsheen, Bour Hannah S, Haslinger Denise, Waltes Regina, Duketis Eftichia, Jarczok Tomas, Sachse Michael, Biscaldi Monica, Degenhardt Franziska, Herms Stefan, Cichon Sven, Ackermann Jörg, Koch Ina, Klauck Sabine M, Freitag Christine M

Abstract excerpt

The genetic architecture underlying Autism spectrum disorder (ASD) has been suggested to differ between individuals with lower (IQ ≤ 70; LIQ) and higher intellectual abilities (IQ > 70; HIQ). Among the identified pathomechanisms, the glutamatergic signalling pathway is of specific interest in ASD. We investigated 187 common functional variants of this neurotransmitter system for association with ASD and with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29147782
DOI: 10.1007/s00702-017-1813-9

Genes

ADCY1
AKAP13
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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