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Tetramethylpyrazine protects mitochondrial function by upregulating TFAM and alleviating nerve cell apoptosis in SBI rats

2022-10-11

Abstract excerpt

Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage and mutation is widely accepted as one of the pathological processes of neurodegenerative diseases. As an mtDNA binding protein, mitochondrial transcription factor A (TFAM) maintains the integrity of mtDNA through transcription, replication, nucleoid formation, damage perception, and DNA repair. In recent works, the overexpression of TFAM increas...

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Literature Corpus work
e14792e7-4681-5b41-9ad1-f30d06b76375
DOI
10.21203/rs.3.rs-2136730/v1
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