Article

Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Allergen-driven IgE–mast cell (MC) activation is a central feature of allergic diseases, whose prevalence continues to increase worldwide. Allergen immunotherapy (AIT) is currently the only disease-modifying treatment and induces a state of MC hyporesponsiveness termed desensitization; however, its underlying molecular mechanisms remain incompletely understood and whether this state reflects pas...

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Literature Corpus work: 11b88931-0faf-5a9e-8055-77976bd21a40
DOI: 10.64898/2026.02.28.708745

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