Article

CREB2 mediates oxidative neuronal death

2025-11-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background.</bold> Glutamate-induced oxidative cytotoxicity is a major contributor to neuronal loss in neurodegenerative diseases. Although the p53–GADD45α pathway has been implicated in this process, the upstream transcriptional regulators that convert oxidative stress signals into neuronal death remain unclear. CREB2 (also known as ATF4) is a stress-responsive transcription f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e11c01c1-bee4-5673-93e0-feb9b7b9ce14
DOI: 10.21203/rs.3.rs-8091091/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CREB2 mediates oxidative neuronal deathDOI 10.21203/rs.3.rs-8091091/v1Read

Cellular, molecular and biochemical impacts of silver nanoparticles on rat cerebellar cortexSemantic proximity Read

NAD+ Improves Cognitive Function and Reduces Neuroinflammation By Ameliorating Mitochondrial Damage and Decreasing ROS Production in Chronic Cerebral Hypoperfusion Models Through Sirt1/PGC-1α PathwaySemantic proximity Read

Germacrone attenuates memory impairment, hippocampal inflammation, and neurological deficits induced by Lipopolysaccharide in miceSemantic proximity Read

Neuroinflammation Induces Myelin Damage by Inhibiting Gapdh of Oligodendrocytes in the HippocampusSemantic proximity Read

CHOP Deletion and Anti-Neuroinflammation Treatment With Hesperidin Synergistically Attenuate NMDA Retinal Injury in MiceSemantic proximity Read

ER Stress, CREB, and Memory: A Tangled Emerging Link in DiseaseSemantic proximity Read

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injurySemantic proximity Read

Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injurySemantic proximity Read

Arsenic Trioxide Underpins Delayed Neuroinflammation and Impaired Synaptic Integrity involving Integrative Stress Response SignalingSemantic proximity Read

Glutamate Increases In Vitro Survival and Proliferation and Attenuates Oxidative Stress-Induced Cell Death in Adult Spinal Cord-Derived Neural Stem/Progenitor Cells via Non-NMDA Ionotropic Glutamate Receptors.Semantic proximity Read

Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells.Semantic proximity Read

HDAC2 Selectively Regulates FOXO3a-Mediated Gene Transcription during Oxidative Stress-Induced Neuronal Cell DeathSemantic proximity Read