Article
Human intronless disease associated genes are slowly evolving.
BMB reports - 30 Jun 2009
Agarwal Subhash Mohan, Srivastava Prashant K
Abstract excerpt
In the present study we have examined human-mouse homologous intronless disease and non-disease genes alongside their extent of sequence conservation, tissue expression, domain and gene ontology composition to get an idea regarding evolutionary and functional attributes. We show that selection has significantly discriminated between the two groups and the disease associated genes in particular exhibit lower K(a)...
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