Article
Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder.
Frontiers in immunology - 1 Jan 2025
Zhang Yangyi, Zhang Fei, Shen Xingyi, Ni Maoyuan, Zhang Jiayi, Zhang Shunling, Lin Jingwen, Yang Zhaoyang, Lei Huangwei
Abstract excerpt
Background: A critical need exists for objective biomarkers and novel therapeutic targets in major depressive disorder (MDD). Although dysfunction in mitochondrial immunometabolism is implicated in MDD, the specific causal genes suitable for clinical translation remain largely unidentified. This study aimed to bridge this gap by identifying mitochondria-related genes that have a causal impact on MDD risk through...
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