Article

S3440P Substitution in C-Terminal Region of Human Reelin Dramatically Impairs Secretion of Reelin from HEK 293T Cells<strong> </strong>

2019-07-01

Abstract excerpt

<h4>Background: </h4> Reelin is a large extracellular glycoprotein secreted by Cajal–Retzius cells and has a main role during brain development, especially in neuronal migration. Reelin is comprised of N-terminal F-spondin like domain, eight tandem repeats, and a highly conserved basic C-terminal region (CTR). The CTR main role in the secretion of Reelin has been investigated by advertently inducing deletion...

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Literature Corpus work: e0fb6a89-7fcd-575e-a9f1-9a9fa58b6f72
DOI: 10.20944/preprints201907.0025.v1

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