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Article

Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

Archives of Iranian medicine - 1 Oct 2020

Esmaeilzadeh-Gharehdaghi Elika, Razmara Ehsan, Bitaraf Amirreza, Jamshidi Ahmadreza, Mahmoudi Mahdi, Garshasbi Masoud

Abstract excerpt

BACKGROUND: Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the RELN gene (OMIM: 600514) which was associated with AS. This study is designed to investigate the potential effect of RELN S2486G mutation on reelin secretion; additionally, we objected to evaluate the phospholipase A2 (PLA2G7) gene (OMIM: 601690) expression and...

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Identifiers

PMID: 33107310
DOI: 10.34172/aim.2020.87

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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