Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein.

Abstract excerpt

Reelin is a secreted glycoprotein that plays essential roles in the brain. Reelin is specifically cleaved at two distinct sites, called N-t and C-t, with the former being the major one. N-t cleavage can occur both in the extracellular space and in the endosomes, although the physiological importance of endosomal N-t cleavage has not been investigated. In this study, we first determined the exact N-t cleavage site...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aspartic Acid
• Share to Cell Adhesion Molecules, Neuronal