Article

AI-Enabled Prediction of Homologous Recombination Deficiency from Histopathology Images

2025-06-19

Abstract excerpt

Identification of patients who will respond to Poly (ADP-ribose) polymerase (PARP) in-hibitor therapy is challenging due to the lack of a unifying morphological pheno-type. Homologous recombination deficiency (HRD), a key biomarker in breast and ovarian cancer, guides therapeutic decisions. Current HRD testing via next-generation sequencing (NGS) is tissue-dependent, has high failure rates, misses relevant HRD gen...

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Literature Corpus work: e0e38696-5f30-56db-90fd-a7fc2a0483ed
DOI: 10.20944/preprints202506.1556.v1

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