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Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images

1 Dec 2022

Abstract excerpt

Homologous recombination DNA-repair deficiency (HRD) is becoming a well-recognized marker of platinum salt and polyADP-ribose polymerase inhibitor chemotherapies in ovarian and breast cancers. While large-scale screening for HRD using genomic markers is logistically and economically challenging, stained tissue slides are routinely acquired in clinical practice. With the objectives of providing a robust...

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PMID: 36516847
DOI: 10.1016/j.xcrm.2022.100872

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