Article

IHGAMP: Pan-cancer HRD prediction from routine H&E whole-slide images using foundation models

2025-12-20

Abstract excerpt

Homologous recombination deficiency (HRD) confers sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, representing a critical biomarker for precision oncology across multiple malignancies. Current HRD assessment relies on next-generation sequencing of genomic scar signatures, but specialized infrastructure requirements, high costs, and prolonged turnaround times limit wid...

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Literature Corpus work: c36f020d-35c7-5ab5-8a1c-51fbb369eb80
DOI: 10.64898/2025.12.19.25342650

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