Article

HRDPath: An Explainable Multi-Model Deep Learning Architecture for Predicting Homologous Recombination Deficiency from Histopathology Images

2025-09-26

Abstract excerpt

Homologous recombination deficiency (HRD) is a critical biomarker for guiding treatment decisions in high-grade serous tubo-ovarian carcinoma (HGSOC), a cancer with few reliable biomarkers. However, existing genomic-based tests for HRD are variable, expensive, and time-consuming. To this end, we developed HRDPath, a novel patient-level deep learning architecture that combines the strengths of two complementary mod...

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Literature Corpus work: 1b695f27-f21e-5bce-8dce-facb1a8ea545
DOI: 10.1101/2025.09.24.678258

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